8c60

Cryo-EM structure of the human SIN3B full-length complex at 3.4 Angstrom resolutionCryo-EM structure of the human SIN3B full-length complex at 3.4 Angstrom resolution

Structural highlights

8c60 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SIN3B_HUMAN SIN3A-related intellectual disability syndrome due to a point mutation.

Function

SIN3B_HUMAN Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.[UniProtKB:Q62141]

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OCA