Gasdermin

Gasdermin (GSDM) is the substrate of the inflamamatory Caspase downstream from inflamasomes which activate caspase. Inflammasomes are supramolecular signaling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis . Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. Structural highlights This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

spinqualitylabelsall models Cryo-EM mouse gasdermin A3 pore complex with cardiolipin (PDB code 6cb8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image