Chorismate mutase

Function Chorismate mutase.(CHM) is a key enzyme in the biosynthesis of aromatic amino acids Phe and Tyr . CHM catalyzes the rearrangement of chorismate to prephenate which is the precursor of Phe and Tyr.. CHM is divided ןמto 2 classes: AroH class which is monofunctional and thק bifunctional AroQ. Structural highlights The 3D structure of the complex of CHM with transition state analog shows the CHM structure containing a dimer of pseudosymmetry but only the N-terminal half contains an available active site pocket. The transition state analog is buried in the active site pocket and forms extensive H-bond network with CHM. Arg 49 and Arg 134 which are part of this network are conserved in all the known CHMs.

spinqualitylabelsall models Bacillus subtilis chorismate mutase complex with transition state analog (PDB code 2fp2). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image