3jaf

Structure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound stateStructure of alpha-1 glycine receptor by single particle electron cryo-microscopy, glycine/ivermectin-bound state

3jaf, resolution 3.80Å Show:Asymmetric Unit Biological Assembly Structural highlights 3jaf is a 5 chain structure with sequence from Danio rerio. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.801Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function GLRA1_DANRE Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:10188956, PubMed:26344198). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Channel activity is potentiated by ethanol (By similarity).[UniProtKB:P23415]