Ribosome recycling factor

Function Ribosome recycling factor (RRF) acts in releasing the ribosome from mRNA after completion of protein synthesis. RRF splits the ribosome into its small and large subunits. RRF is used together with elongation factor G in achieving this separation. RRF is a structural mimic of tRNA but binds to the ribosome differently than the A-site, P-site or E-site tRNA. . . Water molecule is shown as red sphere.

spinqualitylabelsall models E. coli ribosome recycling factor complex with decyloxy-methanol and Hg+2 ion (PDB code 1ek8) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of ribosome recycling factor3D Structures of ribosome recycling factor

Updated on 31-October-2023

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• Ribosome recycling factor
  • 1wih – RRF mitochondrial domain II – mouse - NMR
    
  • 1dd5 – RRF – Thermotoga maritima
    
  • 1eh1 – TtRRF – Thermus thermophilus
    
  • 1ek8 – EcRRF – Escherichia coli
    
  • 1ise – EcRRF (mutant)
    
  • 1ge9 – RRF – Aquifex aeolicus
    
  • 1is1 – RRF – Vibrio parahaemolyticus
    
  • 1wqf, 1wqg, 1wqh, 4kdd – MtRRF - Mycobacterium tuberculosis
    
  • 4kb2, 4kb4, 4kc6, 4kaw – MtRRF (mutant)
    
  • 4gfq – RRF – Bacillus anthracis
    
  • 6vud – RRF – Ehrlichia chafeensis
    
• Ribosome recycling factor in the ribosome
  • 6nu2, 6nu3, 6zs9, 7l20, 7nsi, 7nsh – hRRF in 38S ribosome – human - Cryo-EM
    
  • 7l08, 7nqh, 7nql, 7nsj – hRRF in 55S mitoribosome - Cryo-EM
    
  • 5mlc, 6eri – RRF in 50S ribosome – spinach - Cryo-EM
    
  • 4v54, 4v55, 4v5y, 4v9c, 4v9d – EcRRF in 50S ribosome
    
  • 1t1m, 1zn1 – EcRRF in 70S ribosome – Cryo-EM
    
  • 1zn0, 2rdo – EcRRF in 50S ribosome – Cryo-EM
    
  • 4woi – EcRRF in 50S ribosome + antibiotic
    
  • 3j0d, 3j0e – TtRRF in Ec50S ribosome – Cryo-EM
    
  • 4v5a, 6ucq – TtRRF in 70S ribosome
    
  • 1y69 – RRF in 50S ribosome – Deinococcus radiodurans
    
  • 7pau – RRF in 50S ribosome – Mycoplasma pneumoniae - Cryo-EM