7c3o

Crystal structure of TT109 from CANDIDA ALBICANSCrystal structure of TT109 from CANDIDA ALBICANS

Structural highlights

7c3o is a 1 chain structure with sequence from Candida albicans SC5314. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.89Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RT109_CANAL Histone chaperone-dependent acetylase that modifies 'Lys-56' of histone H3 (H3K56ac), to promote genomic stability, DNA repair and transcriptional regulation during mitotic S-phase (PubMed:20601951, PubMed:20080646). Plays an important role in the regulation of white-opaque genotoxin induced-switching (PubMed:21749487).^[1] ^[2] ^[3]

References

↑ Lopes da Rosa J, Boyartchuk VL, Zhu LJ, Kaufman PD. Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1594-9. PMID:20080646 doi:10.1073/pnas.0912427107
↑ Wurtele H, Tsao S, Lépine G, Mullick A, Tremblay J, Drogaris P, Lee EH, Thibault P, Verreault A, Raymond M. Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy. Nat Med. 2010 Jul;16(7):774-80. PMID:20601951 doi:10.1038/nm.2175
↑ Stevenson JS, Liu H. Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3. Mol Microbiol. 2011 Aug;81(4):1078-91. PMID:21749487 doi:10.1111/j.1365-2958.2011.07754.x

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OCA

[1] Lopes da Rosa J, Boyartchuk VL, Zhu LJ, Kaufman PD. Histone acetyltransferase Rtt109 is required for Candida albicans pathogenesis. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1594-9. PMID:20080646 doi:10.1073/pnas.0912427107

[2] Wurtele H, Tsao S, Lépine G, Mullick A, Tremblay J, Drogaris P, Lee EH, Thibault P, Verreault A, Raymond M. Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy. Nat Med. 2010 Jul;16(7):774-80. PMID:20601951 doi:10.1038/nm.2175

[3] Stevenson JS, Liu H. Regulation of white and opaque cell-type formation in Candida albicans by Rtt109 and Hst3. Mol Microbiol. 2011 Aug;81(4):1078-91. PMID:21749487 doi:10.1111/j.1365-2958.2011.07754.x

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