Pyrococcus furiosus galactokinase in complex with galactose, ADP and magnesiumPyrococcus furiosus galactokinase in complex with galactose, ADP and magnesium
Structural highlights
1s4e is a 9 chain structure with sequence from Pyrococcus furiosus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
GAL1_PYRFU Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Is very specific for its substrate, since it is not able to use D-glucose, D-fructose, D-mannose, 2-deoxy-D-glucose, and D-glucosamine as substrates.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Verhees CH, Koot DG, Ettema TJ, Dijkema C, de Vos WM, van der Oost J. Biochemical adaptations of two sugar kinases from the hyperthermophilic archaeon Pyrococcus furiosus. Biochem J. 2002 Aug 15;366(Pt 1):121-7. PMID:11978175 doi:http://dx.doi.org/10.1042/BJ20011597
