Stimulator of interferon genes

Stimulator of interferon genes (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling. Structural highlights The . Water molecules are shown as red spheres.

spinqualitylabelsall models Structure of human STING CTD complex with c-GMP-AMP (PDB entry 4loh) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of STING3D structures of STING

(Updated on 12-November-2020

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• Stimulator of interferon genes

Domain: CTD 139-379

• • 6nt5 – hSTING – human - Cryo EM
    
  • 4ef5, 4f5w, 4f9e – hSTING CTD
    
  • 4f5e – hSTING CTD (mutant)
    
  • 4jc5, 4kc0 – mSTING CTD - mouse
    
  • 6nt6 – cSTING – chicken – Cryo EM
    
  • 5cfo, 5cfr – saSTING CTD – sea anemone
    
• Stimulator of interferon genes complex with ligand
  • 4ef4, 4f5y, 4f9g, 4emt – hSTING CTD + c-di-GMP
    
  • 4f5d – hSTING CTD (mutant) + c-di-GMP
    
  • 4ksy – hSTING CTD + c-GAMP
    
  • 5bqx – hSTING CTD + c-GMP
    
  • 4loh, 4loi – hSTING CTD + c-di-GMP derivative
    
  • 6cff – hSTING CTD + c-di-AMP
    
  • 6dnk – hSTING CTD + c-GMP-AMP
    
  • 4qxo, 4qxp, 4qxq, 4qxr – hSTING CTD + chemptherapeutic agent DMXAA
    
  • 6dxl, 6dxg – hSTING CTD (mutant) + imidazole derivative
    
  • 6a06 – pSTING CTD + c-GAMP - pig
    
  • 6a05 – pSTING CTD + purine derivative
    
  • 6a04 – pSTING CTD + c-di-GMP
    
  • 6a03, 6iyf – pSTING CTD + c-di-AMP
    
  • 5jej – hSTING residues 342-379 + IRF-3
    
  • 4kby – mSTING CTD + c-di-GMP
    
  • 4loj, 4lok – mSTING CTD + c-di-GMP derivative
    
  • 4yp1 – mSTING CTD + c-di-AMP derivative
    
  • 4lol – mSTING CTD + chemptherapeutic agent DMXAA
    
  • 4kby – mSTING CTD + c-di-GMP
    
  • 6nt7, 6nt8 – cSTING + GMP-AMP – Cryo EM
    
  • 6nt9 – cSTING + TBK1 – Cryo EM
    
  • 5cfl – saSTING CTD + c-di-GMP
    
  • 5cfp – saSTING CTD (mutant) + c-di-GMP
    
  • 5cfq – saSTING CTD + c-AMP-GMP
    
  • 5cfm – saSTING CTD + c-GMP
    
  • 5cfn – saSTING CTD + c-di-AMP