6l49

H3-CA-H3 tri-nucleosome with the 22 base-pair linker DNAH3-CA-H3 tri-nucleosome with the 22 base-pair linker DNA

6l49, resolution 18.90Å Show:Asymmetric Unit Biological Assembly Structural highlights 6l49 is a 26 chain structure with sequence from Homo sapiens and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 18.9Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CENPA_HUMAN Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro). See Also Centromere protein 3D structure Histone 3D structures