User:Nikhil Malvankar/Geobacter pilus structure and function
Interactive 3D Complement in Proteopedia
Structure of novel pili evolved for extracellular translocation of microbial nanowires
Yangqi Gu,
Vishok Srikanth,
Ruchi Jain,
Aldo I. Salazar-Morales,
J. Patrick O'Brien,
Sophia M. Yi,
Rajesh K. Soni,
Fadel A. Samatey,
Sibel Ebru Yalcin,
and Nikhil S. Malvankar.
(journal article link here) (2020).
(DOI link here)
Molecular TourMolecular Tour
Our electron cryomicroscopic structure of Geobacter sulfurreducens pili reveals them to be composed of a core of PilA-N coated with an outer surface layer of PilA-C (. Here is a (front half hidden). The C-termini of PilA-N in PilA-C. The filament is assembled from . Dimer : PilA-N consists of two alpha helices, while PilA-C includes a 3-stranded beta sheet. The C-terminal protrusion of PilA-N is held between two flaps of PilA-C. These flaps might be open before PilA-N arrives to form a dimer, reminiscent of the flaps of HIV protease[1].
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- ↑ Hornak V, Okur A, Rizzo RC, Simmerling C. HIV-1 protease flaps spontaneously open and reclose in molecular dynamics simulations. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):915-20. doi:, 10.1073/pnas.0508452103. Epub 2006 Jan 17. PMID:16418268 doi:http://dx.doi.org/10.1073/pnas.0508452103