6rv4

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237

Structural highlights

6rv4 is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[KCNK3_HUMAN] Heritable pulmonary arterial hypertension. The disease is caused by mutations affecting the gene represented in this entry.

Function

[KCNK3_HUMAN] pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward.^[1] ^[2]

References

↑ Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Sci Signal. 2012 Nov 20;5(251):ra84. doi: 10.1126/scisignal.2003431. PMID:23169818 doi:http://dx.doi.org/10.1126/scisignal.2003431
↑ Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M. TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71. doi: 10.1093/emboj/16.17.5464. PMID:9312005 doi:http://dx.doi.org/10.1093/emboj/16.17.5464

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OCA

[1] Plant LD, Zuniga L, Araki D, Marks JD, Goldstein SA. SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons. Sci Signal. 2012 Nov 20;5(251):ra84. doi: 10.1126/scisignal.2003431. PMID:23169818 doi:http://dx.doi.org/10.1126/scisignal.2003431

[2] Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M. TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J. 1997 Sep 1;16(17):5464-71. doi: 10.1093/emboj/16.17.5464. PMID:9312005 doi:http://dx.doi.org/10.1093/emboj/16.17.5464

[1]

[2]

6rv4

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237

Structural highlights

Disease

Function

References

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6rv4

Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237

Structural highlights

Disease

Function

References

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