2itz
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CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN L858R MUTATION IN COMPLEX WITH IRESSA
DiseaseDisease
Known diseases associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]
About this StructureAbout this Structure
2ITZ is a Single protein structure of sequence from Homo sapiens with CL and IRE as ligands. Active as Receptor protein-tyrosine kinase, with EC number 2.7.10.1 Structure known Active Site: AC2. Full crystallographic information is available from OCA.
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Receptor protein-tyrosine kinase
- Single protein
- Boggon, T.J.
- Eck, M.J.
- Greulich, H.
- Li, Y.
- Meyerson, M.
- Woo, S.
- Yun, C.H.
- CL
- IRE
- Alternative splicing
- Anti-oncogene
- Atp-binding
- Cell cycle
- Disease mutation
- Egfr
- Epidermal growth factor
- Gefitinib
- Glycoprotein
- Iressa
- L858r
- Membrane
- Nucleotide-binding
- Phosphorylation
- Polymorphism
- Receptor
- Transferase
- Transmembrane
- Tyrosine-protein kinase
- Zd1839