4c4w

Structure of a rare, non-standard sequence k-turn bound by L7Ae proteinStructure of a rare, non-standard sequence k-turn bound by L7Ae protein

Structural highlights

4c4w is a 8 chain structure with sequence from Archaeoglobus fulgidus DSM 4304, Homo sapiens and Kneallhazia solenopsae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SNRPA_HUMAN] Binds stem loop II of U1 snRNA. It is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. Binds preferentially to the 5'-UGCAC-3' motif in vitro.^[1]

References

↑ Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

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OCA

[1] Lutz CS, Cooke C, O'Connor JP, Kobayashi R, Alwine JC. The snRNP-free U1A (SF-A) complex(es): identification of the largest subunit as PSF, the polypyrimidine-tract binding protein-associated splicing factor. RNA. 1998 Dec;4(12):1493-9. PMID:9848648

[1]

4c4w

Structure of a rare, non-standard sequence k-turn bound by L7Ae proteinStructure of a rare, non-standard sequence k-turn bound by L7Ae protein

Structural highlights

Function

See Also

References

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4c4w

Structure of a rare, non-standard sequence k-turn bound by L7Ae proteinStructure of a rare, non-standard sequence k-turn bound by L7Ae protein

Structural highlights

Function

See Also

References

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