6nvf

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Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8Crystal structure of Mycobacterium tuberculosis dethiobiotin synthetase in complex with fragment analogue 8

Structural highlights

6nvf is a 4 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Dethiobiotin synthase, with EC number 6.3.3.3
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BIOD_MYCTU] Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring.[1]

References

  1. ↑ Dey S, Lane JM, Lee RE, Rubin EJ, Sacchettini JC. Structural characterization of the Mycobacterium tuberculosis biotin biosynthesis enzymes 7,8-diaminopelargonic acid synthase and dethiobiotin synthetase . Biochemistry. 2010 Aug 10;49(31):6746-60. PMID:20565114 doi:10.1021/bi902097j

6nvf, resolution 1.99Å

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