Endonuclease

Function Endonuclease (ENN) cleaves phosphodiester bond within polynucleotide chain. ENN cleaves DNA at a restriction site which is usually a 6-nucleotide palindrome. ENN is restriction site–specific. Various types of ENN differ by their mechanism of action. ENN is used in genetic engineering to make recombinant DNA. ENN requires a restriction site and a cleavage pattern. ENN-I operates on DNA with separate restriction site and cleavage pattern, while ENN-II operates on overlapping restriction site and cleavage pattern. Some ENNs are encoded within introns thus facilitating their mobility. These ENNs or inteins are designated I-ENN. The Cas ENN proteins are part of CRISPR/Cas prokaryotic immune system which confers protection from foreign genetic elements like viruses. The CRISPR (Clustered Regularly Interspersed Short Palindromic Repeats) are DNA loci which are found in ca. 40% of the bacteria. The CRISPR/Cas system is being used lately as gene editing tool. For more details see CRISPR-Cas CRISPR-Cas Part II Cas9 CRISPR-Cas9 CRISPR type I-E (Cascade) CRISPR type V CRISPR subtype I-A CRISPR subtype I-B CRISPR subtype I-C CRISPR subtype I-F CRISPR subtype III-A (Csm complex) CRISPR subtype III-B (Cmr complex) CRISPR subtype V (Cpf1) CRISPR type VI CRISPR type V (Cpf1) Intron-encoded ENN or homing ENN are encoded by genes with mobile, self-splicing introns. They promote the movement of DNA sequences from one chromosome location to another. See also Apurinic-Apyrimidinic Endonuclease-1 For EcoRV ENN see Student Projects for UMass Chemistry 423 Spring 2012-3 For NEI ENN see DNA repair protein human endonuclease VIII-like 1 (NEIL1). Relevance Sickle cell anemia is caused by mutation in the recognition site of MstII ENN. Disease Mutation in UV-specific ENN causes Xeroderma pigmentosa. Mutations in tRNA-splicing ENN cause pontocerebellar hypoplasia. Structural highlights (PDB code 1rva). 3D structures of endonuclease Endonuclease 3D structures

spinqualitylabelsall models E. coli EcoRV endonuclease dimer (magenta, green) complex with DNA, (PDB code 1rva) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of endonuclease3D structures of endonuclease

Updated on 19-June-2019 {{#tree:id=OrganizedByTopic|openlevels=0|

• ENN-I

• • 1bix - hENN – human
    
  • 5um9, 5kse, 5k97 – hENN (mutant) + DNA
    
  • 1cfr – ENN – Citrobacter freundii
    
  • 1af5 - CrENN – Chlamydomonas reinhardtii
    
  • 1fzr, 1m0d, 1m0i, 3cae – T7ENN - Enterobacteria phage T7
    
  • 2g7e, 2g7f – VcENN – Vibrio cholera
    
  • 2vnd - VcENN (mutant)
    
  • 2pu3 - VsENN – Vibrio salmonicida

• ENN-II

• • 1pvi, 1pvu - ENN – Proteus vulgaris
    
  • 2wsh - T4ENN (mutant) - Enterobacteria phage T4
    
  • 3w52, 4cwm, 4cxo, 4cxp, 4cxv – ENN – Arabidopsis thaliana
    

• ENN-III

• • 2abk, 1ako - EcENN – Escherichia coli
    
  • 1orn, 1orp, 1p59 - GsENN + DNA – Geobacillus stearothermophilus
    
  • 4unf – DrENN-1 – Deinococcus radiodurans
    
  • 4uob – DrENN-3
    

• ENN-IV

• • 1qtw - EcENN
    
  • 2nqh - EcENN (mutant)
    
  • 1qum – EcENN + DNA
    
  • 2nqj, 2nq9, 4k1g - EcENN (mutant) + DNA
    
  • 1xp3 - ENN – Bacillus anthracis
    
  • 3aal - GkENN – Geobacillus kaustophilus
    
  • 3aam - TtENN – Thermus thermophilus

• ENN-V

• • 4nsp – hENN catalytic domain
    
  • 1eni, 1enj, 1enk, 2end - T4ENN
    
  • 1vas - T4ENN + DNA
    
  • 2w35, 2w36, 4b20 - TmENN + DNA – Thermotoga maritima
    
  • 3hd0 - TmENN
    
  • 3ga2 - BsENN (mutant) – Bacillus subtilis
    
  • 3goc - ENN – Streptomyces avermitilis
    
  • 2fcc – T4ENN + DNA
    

• ENN-VII

• • 1en7, 1e7d - T4ENN
    
  • 1e7l - T4ENN (mutant)
    
  • 2qnc, 2qnf - T4ENN (mutant) + DNA

• ENN-VIII

• • 1tdh – hENN
    
  • 1bix – hENN + DNA
    
  • 1q39, 1q39 - EcENN
    
  • 1q3b, 1q3c - EcENN (mutant)
    
  • 1k3x, 2ea0, 1k3w, 1k3x, 2ea0, 2opf, 2oq4 - EcENN + DNA
    
  • 2opf, 2oq4, 6fbu - EcENN (mutant) + DNA

• AP ENN

• • 3ngf - ENN - Brucella melitensis
    
  • 2j63 – ENN – Leishmania major
    

• Cas ENN

• • 1wj9, 4ej3 – TtCas
    
  • 4n06 – AfCas1 - Archaeoglobus fulgidus
    
  • 3god – PaCas1 – Pseudomonas aeruginosa
    
  • 3nkd – EcCas1
    
  • 4wj0 – PhCas1 - Pyrococcus horikoshii
    
  • 4xtk – TmCas1
    
  • 5fcl – Cas1 - Pectobacterium atrosepticum
    
  • 4zkj - SpCas1 – Streptococcus pyogenes
    
  • 3oq2 – Cas2 – Desulfovibrio vulgaris
    
  • 4mak – EcCas2
    
  • 4p6i, 4qdl – EcCas1 + EcCas2
    
  • 6qy3 – GsCas1 + EcCas2 + Csn2 – Cryo EM
    
  • 3s4l – MjCas3 – Methanocaldococcus jannaschii
    
  • 4qqw – TfCas3 – Thermobifida fusca
    
  • 4qqx – TfCas3 + ATP
    
  • 4qqy – TfCas3 + ADP
    
  • 4qqz – TfCas3 + AMPPNP
    
  • 4q2c - TteCas3 – Thermobaclum terrenum
    
  • 4q2d - TteCas3 + ATP
    
  • 3i4h – Cas4 - Pyrobaculum calidifontis<br /
  • 4qr0, 4qr1 - SpCas9 (Csn1) – Streptococcus pyogenes
    
  • 4ilr, 3zfv – SsCas6
    
  • 3i4h – PfCas6 - Pyrococcus furiosus
    
  • 4dzd – EcCas6e
    
  • 4qr0, 4qr1 - SpCas9 (Csn1) – Streptococcus pyogenes
    
  • 4qr0, 4qr1, 4cmp, 4cmq - SpCas9
    
  • 4ogc, 4oge – Cas9 II-C – Actinomyces naeslundii
    
  • 3ung, 3ur3, 4doz, 4w8y – PfCas10 CMR2 subunit
    
  • 4h4k – PfCas10 CMR2+CMR3 subunits
    
  • 3w2v – PfCas10 CMR2+CMR3 subunits + AMP
    
  • 3w2w – PfCas10 CMR2+CMR3 subunits + ATP
    
  • 4gkf – PfCas10 CMR5 subunit
    
  • 4an8, 4f3e – TtCasA (Cse1)
    
  • 4h3t - CasA (Cse1) – Acidimicrobium ferrooxidans
    
  • 4h79 - TfCasB (Cse2)
    
  • 3wa8 - CasB (Cse2) – Meiothermus ruber
    
  • 4h7a - TtCasB (Cse2)
    
  • 4tvx – EcCasA (Cse1) + CasE
    
  • 3qhq - Csn2 – Streptococcus agalactiae
    
  • 3toc, 3v7f – SpCsn2
    
  • 3ps0 – SsCsa2
    

• Cas ENN complex with RNA and DNA

• • 5dlj, 5dqt, 5dqu, 5dqz, 5ds4, 5ds5, 5ds6, 5vvl, 5vvk, 5vvj – EcCas1 + EcCas2 + DNA
    
  • 5wfe – EcCas1 + EcCas2 + IHF-a + IHF-b + DNA
    
  • 5xvp, 5xvo, 5xvn – Cas1 + Cas2 + DNA – Enterococcus faecalis
    
  • 6qxt, 6qxf – GsCas1 (mutant) + EcCas2 + Csn2 + DNA – Cryo EM
    
  • 4ill, 4ilm – SsCas6 + RNA - Sulfolobus solfataricus
    
  • 5uz9 – PaCsa5f + Cas7f + Cas8f + anti-crispr protein + RNA - Cryo EM
    
  • 6b48, 6b47, 6b46, 6b45 – PaCsa6 + Csy1 + Csy2 + Csy3 + anti-crispr protein + RNA - Cryo EM
    
  • 6b44 – PaCsa6 + Csy1 + Csy2 + Csy3 + anti-crispr protein + DNA - Cryo EM
    
  • 6ne0 – PaCsa6/Csy4 + Csy1 + Csy2 + Csy3 + DNA + RNA – Cryo EM
    
  • 3pkm – PfCas6 + RNA
    
  • 2y8w, 2y8y, 3qrp, 3qrq, 2qrr – TtCas6e (Cse3) + RNA
    
  • 2xli, 2xlj, 2xlk, 4al7 – PaCas6f (Csy4) + RNA
    
  • 4al5, 4al6 - PaCas6f (Csy4) (mutant) + RNA
    
  • 4zt0 - SpCas9 + RNA
    
  • 4zt9 - SpCas9 (mutant) + RNA
    
  • 5f9r - SpCas9 + RNA + DNA
    
  • 4oo8, 4un3, 4un4, 4un5, 5fw1, 5fw2, 5fw3, 5fq5, 5b2r, 5b2s, 5b2t, 5y36, 6ia6 - SpCas9 (Csn1) (mutant) + RNA + DNA
    
  • 5xbl - SpCas9 + associated protein + RNA
    
  • 6ifo - SpCas9 + AcriiA2 + RNA
    
  • 5vw1 - SpCas9 + AcriiA4 + RNA
    
  • 6mcc, 5vzl, 6mcb - SpCas9 + AcriiA4 + RNA – Cryo EM
    
  • 5vgb - NmCas9 + AcriiC1 – Neisseria meningitidis
    
  • 6jdx, [[6jdj], 6j9m] - NmCas9 + AcriiC2
    
  • 6j9n - NmCas9 + AcriiC3
    
  • 5x2h, 5x2g – Cas9 + RNA + DNA – Campylobacter jejuni
    
  • 5czz - SaCas9 (Csn1) + RNA + DNA - Staphylococcus aureus
    
  • 5axw - SaCas9 (Csn1) (mutant) + RNA + DNA
    
  • 6joo - Cas9 + RNA + DNA – Corynebacterium diphtheriae
    
  • 5b2o, 5b2p, 5b2q - FtCas9 (mutant) + RNA + DNA – Francisella tularensis
    
  • 6i1l, 6i1k, 6gtg, 6gtf, 6gte, 6gtd, 6gtc – FtCas12a (mutant) + RNA + DNA
    
  • 4u7u – EcCasA (Cse1) + CasB + CasC + CasD + CasE + RNA
    
  • 4qyz, 5h9f, 5h9e – EcCasA (Cse1) + CasB + CasC + CasD + CasE + RNA + DNA
    
  • 5wqe – AaCas C2C1 + RNA – Alicyclobacillus acidoterrestris
    
  • 5u34 – AaCas C2C1 (mutant) + RNA
    
  • 5u30, 5u31, 5u33 – AaCas C2C1 + RNA + DNA
    
  • 5kk5, 5b43 – AcCas Cpf1 + RNA + DNA – Acidaminococcus
    
  • 5xh7, 5xh6 – AcCas Cpf1 (mutant) + RNA + DNA
    
  • 5ng6 – FtCas Cpf1 + RNA
    
  • 5nfv, 5mga – FtCas Cpf1 + RNA + DNA
    

• EcoKI ENN

• • 2ar0 – EcENN (mutant)
    

• Ecoo109I ENN

• • 1wtd - EcENN
    
  • 1wte – EcENN + DNA
    

• EcoRI ENN

• • 1qc9 - EcENN
    
  • 1eri, 1ckq, 1cl8, 1qps – EcENN + DNA
    
  • 1qrh, 1qri, 2oxv - EcENN (mutant) + DNA

• EcoRII ENN

• • 1na6 – EcENN
    
  • 3hqf, 3hqg - EnENN + DNA

• EcoRV ENN

• • 1rve, 1az3 – EcENN
    
  • 1az4 - EcENN (mutant)
    
  • 2rve, 4rve, 1rva, 1rvb, 1rvc, 1az0, 1bsu, 1bua, 1bgb, 1rv5, 1b94, 1b95, 1eo3, 1eo4, 1eon, 1eoo, 1eop, 2b0d, 2b0e, 5hlk - EcENN + DNA
    
  • 1bss, 1b96, 1b97, 1stx, 1suz, 1sx5, 1sx8, 2ge5 - EcENN (mutant) + DNA
    
  • 5f8a - EcENN + DNA + Lu
    

• BamHI ENN

• • 1bam – BaENN – Bacillus amyloliquefaciens
    
  • 1bhm, 3bam, 2bam, 1esg - BaENN + DNA

• Bbvci ENN

• • 6mag, 6m9g, 6eg7 – BbENN subunit 2 – Brevibacillus brevis
    
  • 6maf – BbENN subunits 1+2
    

• FokI ENN

• • 1fok – PoENN + DNA – Planomicrobium okeanokoites
    
  • 2fok – PoENN

• LAGLIDAD ENN

• • 4z1x – fyENN + DNA – fission yeast
    
  • 5e5o – ENN + DNA – Sordaria macropora
    

• PvuII ENN

• • 3pvi - PvENN (mutant) + DNA – Proteus vulgaris
    
  • 1k0z, 1h56, 3ksk - PvENN
    
  • 1ni0 - PvENN (mutant)
    
  • 2pvi, 1eyu, 1f0o - PvENN + DNA

• tRNA-splicing ENN

• • 2gw6 – hENN subunit sen15 – NMR
    
  • 1a79, 1a76, 1a77 - MjENN – Methanocaldococcus jannaschii
    
  • 2cv8 - ENN – Sulfolobus tokodaii
    
  • 2gjw - AfENN + RNA – Archaeoglobus fulgidus
    
  • 1r0v, 1r11 – AfENN
  • 2ohc, 2ohe - TaENN – Thermoplasma acidophilum
    
  • 2zyz – ENN – Pyrobaculum aerophilum
    
  • 3iey - ENN + NEQ261 – Nanoarchaeum equitans
    
  • 3ajv - ApENN (mutant) – Aeropyrum pernix
    
  • 3p1y - ApENN /AfENN
    
  • 3p1z - ApENN + protein

• VSR ENN

• • 1vsr – EcENN
    
  • 1cw0 - EcENN + DNA

• BglI ENN

• • 1dmu, 1d2i – BsENN + DNA
    
  • 1dfm - BsENN (mutant) + DNA

• BglII ENN

• • 1es8 - BsENN

• MunI ENN

• • 1d02 - ENN (mutant) + DNA - Mycoplasma

• Sm ENN

• • 1smn, 1qae, 1ql0, 1g8t – ENN – Serratia marcescens

• NaeI ENN

• • 1ev7 - LaENN – Lechevalieria aerocolonigenes
    
  • 1iaw - LaENN + DNA

• NgoMIV ENN

• • 1fiu, 4abt - ENN + DNA – Neisseria gonorrheae

• NEI ENN

• • 1tdh - hENN

• BsoBI ENN

• • 1dc1 - GsENN + DNA

• Bse634I ENN

• • 1knv – GsENN
    
  • 3v1z – GsENN + DNA
    
  • 3v20, 3v21 - GsENN (mutant) + DNA

• HincII ENN

• • 1kc6, 1tw8, 1xhu, 1xhv, 1tx3, 2gie - HiENN + DNA – Haemophilus influenza
    
  • 2gig, 2gih, 2gii, 2gij, 3e3y, 3e40, 3e41, 3e42, 3e43, 3e44, 3e45, 3ebc - HiENN (mutant) + DNA
    
  • 2aud – HiENN

• HinDIII ENN

• • 2e52, 3a4k - HiENN + DNA

• HinP1I ENN

• • 1ynm – HiENN
    
  • 2fkc, 2fkh, 2fl3, 2flc - HiENN + DNA

• Flap ENN

• • 5zod - hENN
    
  • 3q8k, 3q8l, 3q8m - hENN + DNA
    
  • 5zog, 5zof, 5zoe - hENN (mutant) + DNA
    
  • 5fv7 - hENN + inhibitor
    
  • 1ul1 - hENN + PCNA
    
  • 1mc8 - PhENN (mutant)
    
  • 3ory– ENN – Desulfurococcus amylolyticus
    
  • 1rxv, 1rxw - AfENN + DNA
    
  • 2izo - SsENN + PCNA – Sulfolobus solfataricus
    
  • 1a76, 1a77 - MjENN
    
  • 1b43 – PfENN – Pyrococcus furiosus
    
  • 1rxz - AfENN + PCNA
    
  • 4wa8 – ENN – Methanopyrus kandleri
    

• DNA mismatch ENN

• • 1h7u – hENN
    
  • 6mfq – hENN Pms2
    
  • 5u5r – hENN + importin
    
  • 1odg - EcENN + DNA
    

• Vvn ENN

• • 1ouo – VvENN – Vibrio vulnificus
    
  • 1oup, 2ivk - VvENN + DNA

• Structure-specific ENN

• • 4zou – hENN SLX4 subunit BTB domain
    
  • 4uyi – hENN SLX4 subunit BTB domain (mutant)
    
  • 4xm5 – CgENN SLX1 subunit – Candida glabrata
    
  • 4xlg – CgENN SLX1 (mutant)+SLX4 subunits
    
  • 4zdt – fyENN SLX1+SLX4 subunits
    

• BfiI ENN

• • 2c1l – ENN – Bacillus firmus

• SfiI ENN

• • 2ezv, 2f03 – ENN + DNA – synthetic

• Ecl18kI ENN

• • 2fqz, 2gb7 – ENN + DNA – Enterobacter cloacae

• SdaI ENN

• • 2ixs – ENN – Streptomyces diastaticus

• PabI ENN

• • 2dvy – ENN – Pyrococcus abyssi

• PspGI ENN

• • 3bm3 – ENN – Pyrococcus

• HNH ENN

• • 4h6d – ENN – Geobacter metallireducens
    
  • 5h0o, 5h0m – ENN – Geobacillus virus E2
    
  • 5cxr – ENN + pyrazole derivative – Influenza virus
    
  • 6j9l] - NmENN + AcriiC2
    

• UV damage ENN

• • 2j6v, 3bzg, 3c0s – TtENN
    
  • 3bzj, 3c0l, 3c0q - TtENN (mutant)
    
  • 3tc3 - SaENN
    
  • 4gle - SaENN + DNA
    

• NotI ENN

• • 3bvq - NoENN – Nocardia otitidiscaviarum
    
  • 3c25 - NoENN + DNA

• BpujI ENN

• • 2vla, 3s1s – BpENN – Bacillus pumilus
    
  • 5hnf, 5hnh, 5hlt – BpENN + DNA
    

• Sau3AI ENN

• • 2reu – SaENN C terminal – Staphylococcus aureus
    
  • 4pxg – SaENN (mutant)
    

• HpyI ENN

• • 3fc3, 3gox – HpENN99 + DNA – Helicobacter pylori
    
  • 3or3 – HpENN88 + DNA

• PacI ENN

• • 3ldy, 3m7k - PaENN + DNA – Psdeudomonas alcaligenes

• Crossover junction ENN

• • 2ziw, 2zix, 2ziu – hENN EME1 + Mus81
    
  • 2ziv – hENN EME1 (mutant) + Mus81
    
  • 4p0p, 4p0q, 4p0r, 4p0s – hENN EME1 + Mus81 + DNA
    
  • 2kpf - mENN – mouse
    

• OkrAI ENN

• • 3odh - ENN + DNA – Oceanobacter kriegii

• BspD6I ENN

• • 2ewf - ENN – Bacillus

• ThaI ENN

• • 3ndh - TaENN + DNA

• Xpf ENN

• • 1z00, 2a1j - hENN C terminal + DNA excision repair protein
    
  • 2aq0 – hENN residues 823-905 – NMR
    
  • 2kn7 – hENN residues 823-905 + DNA – NMR
    
  • 2bgw - ApENN + DNA
    
  • 2bhn - ApENN
    

• Mazf3 ENN

• • 5uct, 5cca - MtENN – Mycobacterium tuberculosis
    

• Vapc ENN

• • 5wzf, 5wz4 – MtENN-20
    
  • 5ed0, 5ecy – SfENN – Shigella flexneri
    
  • 5ecy, 5ecw, 5ecd – SfENN (mutant)
    

• Muts2 ENN

• • 4och, 4od6 - DrENN SMR domain
    

• Endoms ENN

• • 5gkj – TkENN (mutant) – Thermococcus kodakarensis
    
  • 5gke, 5gkf, 5gkg, 5gkh, 5gki – TkENN (mutant) + DNA
    

• ENN G

• • 5gkc, 4qn0 – CeENN (mutant) – Caenorhabdfitis elegans
    
  • 5gkp – CeENN (mutant) + DNA
    

• ENN S

• • 5ybb – ENN + R-M system + DNA – Caldanaerobacter subterraneus
    

• ENN V

• • 5aoy – mENN (mutant)
    
  • 4xpu – EcENN
    

• Apurinic-apyrimidinic ENN

• • 5cfg, 6mk3, 6mkk, 6mkm, 6mko – hENN
    
  • 5dff, 5dfh, 5dfi, 5dfj, 5dg0, 5wn5, 5wn4, 5wn3, 5wn2, 5wn1, 5wn0, 6bos – hENN + DNA
    
  • 6bot, 6boq, 6bor, 6bou, 6bov, 6bow – hENN (mutant) + DNA
    

• Intron-encoded endonuclease

• I-PpoI ENN

• • 1a74, 1ipp, 1a73, 1cz0 - PpENN + DNA – Physarum polycephalum
    
  • 1cyq, 1evw, 2o6m - PpENN (mutant) + DNA
    
  • 1evx - PpENN

• I-CreI ENN

• • 1bp7, 1g9y, 1g9z, 1n3e, 1n3f, 2vbj, 2vbl, 2vbn, 2vbo, 4aqu, 4aqx - CrENN + DNA
    
  • 1u0c, 1u0d, 1t9i, 1t9j, 2i3p, 2i3q, 4aab, 4aad, 4aae, 4aaf, 4aag, 6fb9, 6fb8, 6fb7, 6fb6, 6fb5, 6fb2, 6fb1, 6fb0 - CrENN (mutant) + DNA
    
  • 2o7m - CrENN

• I-CeuI ENN

• • 2ex5 - ENN (mutant) + DNA – Chlamydomonas eugametos

• I-DmoI ENN

• • 1b24, 2vs7, 2vs8, 4un7, 4un8, 4un9, 4una, 4unb, 4unc, 4ut0, 4d6n, 4d6o, 5ak9, 5a0w, 5o6g, 5o6i - DmENN + DNA – Desulfurococcus mobilis
    
  • 5akf, 5akm, 5akn - DmENN (mutant) + DNA
    
  • 1mow – DmENN/CrENN + DNA

• I-AniI ENN

• • 1p8k, 2qoj, 3uvf - EnENN + DNA – Emericella nidulans
    
  • 3eh8 - EnENN (mutant) + DNA

• I-HmuI ENN

• • 1u3e - ENN + DNA – Bacillus phage spo1

• I-TevI ENN

• • 1i3j, 1t2t - T4ENN + DNA
    
  • 1ln0, 1mk0 – T4ENN (mutant)

• I-SceI ENN

• • 1dfa, 1ef0 – yENN – yeast
    
  • 1gpp – yENN (mutant)
    
  • 1lws, 1lwt, 1r7m, 3c0w, 3c0x, 3ool, 5a0m - yENN + DNA
    
  • 3oor - yENN (mutant) + DNA

• I-PkoII ENN

• • 2cw7, 2cw8 – TkENN

• I-MspI ENN

• • 1sa3, 1yfi, 2fld – ENN + DNA – Moraxella

• I-PfuI ENN

• • 1dq3 – PfENN

• I-Tsp061I ENN

• • 2dch – ENN – Thermoproteus

• I-Vdi141I ENN

• • 3e54 – ENN – Vulcanisaeta distribute

• I-MtuI ENN

• • 3ifj, 3igd - MtENN (mutant)
    
  • 2l8l - MtENN

• I-MsoI ENN

• • 1m5x, 3fd2 – MoENN + DNA – Monomastix
    
  • 3ko2 – MoENN (mutant) + DNA

• I-GzeMII ENN

• • 4efj – ENN + DNA – Gibberella zeae

• I-tRNA ENN

• • 4fz2 – ENN – Candidatus micrarchaeum
    

• I-Cvui ENN

• • 5a78, 5a72, 5a74, 5a77, 5a78 – ENN + DNA – Chlorella vulgaris
    

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