5qgo
PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with OX-220PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) -- Crystal Structure of NUDT7 in complex with OX-220
Structural highlights
Function[NUDT7_HUMAN] Coenzyme A diphosphatase which mediates the cleavage of CoA, CoA esters and oxidized CoA with similar efficiencies, yielding 3',5'-ADP and the corresponding 4'-phosphopantetheine derivative as products. CoA into 3',5'-ADP and 4'-phosphopantetheine. Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester. May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (By similarity). |
| ||||||||||||||||||
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Large Structures
- Aimon, A
- Arrowsmith, C H
- Bountra, C
- Bradley, A R
- Brandao-Neto, J
- Brennan, P E
- Collins, P
- Delft, F von
- Douangamath, A
- Edwards, A
- Elkins, J
- Fairhead, M
- Huber, K
- Krojer, T
- London, N
- Nelson, A
- Ruda, G F
- Saez, L Diaz
- Spencer, J
- Srikannathasan, V
- Szommer, T
- Talon, R
- Hydrolase
- Nudix domain
- Pandda
- Sgc - diamond i04-1 fragment screening
- Xchemexplorer