5nb1

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Crystal structures of homooligomers of collagen type IV. alpha4NC1Crystal structures of homooligomers of collagen type IV. alpha4NC1

Structural highlights

5nb1 is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:COL4A4 (HUMAN)
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

[CO4A4_HUMAN] Benign familial hematuria;Autosomal dominant Alport syndrome;Autosomal recessive Alport syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.

Function

[CO4A4_HUMAN] Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

5nb1, resolution 2.82Å

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OCA