2nui
X-ray Structure of synthetic [D83A]RNase A
OverviewOverview
The total chemical synthesis of RNase A using modern chemical ligation methods is described, illustrating the significant advances that have been made in chemical protein synthesis since Gutte and Merrifield's pioneering preparation of RNase A in 1969. The identity of the synthetic product was confirmed through rigorous characterization, including the determination of the X-ray crystal structure to 1.1 Angstrom resolution. (c) 2007 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 90:278-286, 2008.This article was originally published online as an accepted preprint. The "Published Online" date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com.
About this StructureAbout this Structure
2NUI is a Single protein structure. Full crystallographic information is available from OCA.
ReferenceReference
Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A., Boerema DJ, Tereshko VA, Kent SB, Biopolymers. 2008;90(3):278-86. PMID:17610259 Page seeded by OCA on Sun May 4 09:55:37 2008