6ao6

Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM)Crystal structure of H108A peptidylglycine alpha-hydroxylating monooxygenase (PHM)

Structural highlights

6ao6 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Activity:	Peptidylglycine monooxygenase, with EC number 1.14.17.3
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[AMD_RAT] Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.

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