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6gdi

Revision as of 10:30, 23 May 2018 by OCA (talk | contribs)

Structure of P-glycoprotein(ABCB1) in the post-hydrolytic stateStructure of P-glycoprotein(ABCB1) in the post-hydrolytic state

Structural highlights

6gdi is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Activity:Xenobiotic-transporting ATPase, with EC number 3.6.3.44
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[MDR1A_MOUSE] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.[1]

References

  1. ↑ Aller SG, Yu J, Ward A, Weng Y, Chittaboina S, Zhuo R, Harrell PM, Trinh YT, Zhang Q, Urbatsch IL, Chang G. Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding. Science. 2009 Mar 27;323(5922):1718-22. PMID:19325113 doi:323/5922/1718

6gdi, resolution 7.90Å

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