Liver X receptor

Function Liver X receptprs (LXR) are ligand-activated transcription factors of the nuclear receptor family. There are two LXR isoforms α and β which form heterodimers with retinoic X receptor upon activation and bind to the LXR response element found in the promoter region of the target genes. LXR is a lipogenic transcription factor. LXRs modulate the expression of genes in cholesterol and lipid metabolism in response to changes in cellular cholesterol status. Disease Treatment of mice demonstrating Wilson disease with LXR agonist reduced disease manifestations without worsening neurological symptoms associated with the conventional therapy based on copper chelation. Relevance LXRs have emerged as promising drug targets for anti-atherosclerotic therapies.

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3D Structures of liver X receptpr3D Structures of liver X receptpr

Updated on 17-December-2017

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• Liver X receptor α
  • 2acl – mLXR + retinoic X receptor α + agonist – mouse
    
  • 5avl, 5avl, 5hjs, 3ipq, 3ips, 3ipu – hLXR LBD + NCOA-1 peptide + agonist
    
  • 1uhl – hLXR LBD + retinoic X receptor β + NCOA-2
    
• Liver X receptor β
  • 1upv, 1upw, 5jy3, 3kfc, 4rak – hLXR LBD + agonist – human
    
  • 1pq6, 1pqc, 1pq9 – hLXR LBD + ligand
    
  • 5i4v – hLXR LBD + retinoic X receptor β + agonist
    
  • 5kyj, 5kya – hLXR LBD + retinoic X receptor β + modulator
    
  • 3fal – hLXR LBD + retinoic X receptor β + modulator + retinoic acid
    
  • 5hjp – hLXR LBD + retinoic X receptor β + agonist
    
  • 4nqa – hLXR LBD + retinoic X receptor β + NCOA-2 peptide + DNA
    
  • 4dk7, 4dk8 – hLXR LBD + NCOA-1 peptide + agonist
    
  • 1p8d – hLXR LBD + NCOA-1 peptide + cholesterol derivative