3fk2
Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1
Structural highlights
Function[RHG35_HUMAN] Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'. May participate in the regulation of retinal development and degeneration. May transduce signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP). May also act as a tumor suppressor.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References |
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OCACategories:
- Human
- Large Structures
- Arrowsmith, C H
- Bochkarev, A
- Bountra, C
- Edwards, A M
- Loppnau, P
- Nedyalkova, L
- Park, H
- Structural genomic
- Tempel, W
- Tong, Y
- Weigelt, J
- Alternative splicing
- Anti-oncogene
- Cell cycle
- Cytoplasm
- Dna-binding
- Gtpase activation
- Gtpase-activating protein
- Hydrolase activator
- Nucleus
- Phosphoprotein
- Repressor
- Sgc
- Signaling protein
- Transcription
- Transcription regulation