5v2s

Crystal structure of glycoprotein B from Herpes Simplex Virus type ICrystal structure of glycoprotein B from Herpes Simplex Virus type I

Structural highlights

5v2s is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Related:	6bm8
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[A1Z0P7_HHV1] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moities of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.[HAMAP-Rule:MF_04032]

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OCA