3dax
Crystal structure of human CYP7A1Crystal structure of human CYP7A1
Structural highlights
Function[CP7A1_HUMAN] Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis.[1] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCACategories:
- Cholesterol 7-alpha-monooxygenase
- Human
- Arrowsmith, C H
- Bochkarev, A
- Bountra, C
- Dombrovski, L
- Dong, A
- Edwards, A M
- Loppnau, P
- Park, H
- Structural genomic
- Strushkevich, N V
- Tempel, W
- Wilkstrom, M
- Cholesterol
- Cholesterol 7-alpha hydroxylase
- Cholesterol metabolism
- Cytochrome p450
- Endoplasmic reticulum
- Heme
- Iron
- Lipid metabolism
- Membrane
- Metal-binding
- Microsome
- Monooxygenase
- Nadp
- Oxidoreductase
- Polymorphism
- Sgc
- Steroid metabolism