4m4c

Crystal structure of Rhodostomin ARGDP mutantCrystal structure of Rhodostomin ARGDP mutant

Structural highlights

4m4c is a 4 chain structure with sequence from Agkistrodon rhodostoma. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:	RHOD (Agkistrodon rhodostoma)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VM2RH_CALRH] Metalloproteinase rhodostoxin: snake venom metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Disintegrin rhodostomin: inhibit platelet aggregation induced by ADP, thrombin, platelet-activating factor and collagen. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3).

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OCA