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Structural basis of Zika and Dengue virus potent antibody cross-neutralizationStructural basis of Zika and Dengue virus potent antibody cross-neutralization
Structural highlights
Publication Abstract from PubMedDengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex and fully neutralized virus produced in either insect cells or primary human cells, with 50% neutralization in the low picomolar range. Our results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized. A new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.,Dejnirattisai W, Wongwiwat W, Supasa S, Zhang X, Dai X, Rouvinsky A, Jumnainsong A, Edwards C, Quyen NT, Duangchinda T, Grimes JM, Tsai WY, Lai CY, Wang WK, Malasit P, Farrar J, Simmons CP, Zhou ZH, Rey FA, Mongkolsapaya J, Screaton GR Nat Immunol. 2015 Feb;16(2):170-7. doi: 10.1038/ni.3058. Epub 2014 Dec 15. PMID:25501631[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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