Pantothenate kinase
FunctionFunction
Pantothenate kinase (PanK) phosphorylates pantothenate (vitamin B5) (PAU) to form 4’-phosphopantothenate (PPT) using ATP as phosphate source. This is the first step in coenzyme A biosynthesis[1].
Three types of PanK are known.
- PanK I found in bacteria
- PanK II found mostly in eukaryotes
- PanK III found in bacteria and known as CoaX.
DiseaseDisease
Mutations in PanK II cause the autosomal-recessive disorder Pantothenate kinase-associated neurodegeneration[2].
Structural highlightsStructural highlights
Pantothenate binds in a buried pocket at the PanK dimer interface[3].
3D structures of pantothenate kinase3D structures of pantothenate kinase
Updated on 14-June-2016
ReferencesReferences
- ↑ . PanK is regulated by feedback inhibition by CoA and its thioesters.PMID:9890959
- ↑ Pellecchia MT, Valente EM, Cif L, Salvi S, Albanese A, Scarano V, Bonuccelli U, Bentivoglio AR, D'Amico A, Marelli C, Di Giorgio A, Coubes P, Barone P, Dallapiccola B. The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration. Neurology. 2005 May 24;64(10):1810-2. PMID:15911822 doi:http://dx.doi.org/10.1212/01.WNL.0000161843.52641.EC
- ↑ Hong BS, Yun MK, Zhang YM, Chohnan S, Rock CO, White SW, Jackowski S, Park HW, Leonardi R. Prokaryotic type II and type III pantothenate kinases: The same monomer fold creates dimers with distinct catalytic properties. Structure. 2006 Aug;14(8):1251-61. PMID:16905099 doi:10.1016/j.str.2006.06.008