Metabotropic glutamate receptor

Structure of the glycosylated rat binding domain of the Metabotropic Glutamate Receptor, GluR1, bound to glutamate, Hepes and Mg+2 ions (1ewk)

Drag the structure with the mouse to rotate

FunctionFunction

Metabotropic glutamate receptors are glutamate receptors that activate ion channels indirectly through a signaling cascade involving G proteins^[1]. They are members of the large class of seven-transmembrane domain receptors, the G protein-coupled receptors. Glutamate receptors are classified into 3 groups based on their homology, mechanism and pharmacological properties. See also Ligand Binding N-Terminal of Metabotropic Glutamate Receptors.

Metabotropic glutamate receptor 1 and metabotropic glutamate receptor 5 belong to group I and activate phospholipase C.
Metabotropic glutamate receptor 2 and metabotropic glutamate receptor 3 belong to group II and inhibit the cyclic AMP cascade.
Metabotropic glutamate receptor 7 belongs to group III and inhibits adenylate cyclase activity.

Articles in Proteopedia concerning Toll-like Receptors include:

Glutamate is bound to GluR1 in the crevice between the N-terminal and C-terminal domains^[2].

Updated on 21-April-2016

↑ Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan H, Myers SJ, Dingledine R. Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev. 2010 Sep;62(3):405-96. doi: 10.1124/pr.109.002451. PMID:20716669 doi:http://dx.doi.org/10.1124/pr.109.002451
↑ Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 2000 Oct 26;407(6807):971-7. PMID:11069170 doi:10.1038/35039564