Glycolate oxidase

Function Glycolate oxidase (GOX) catalyzes the conversion of (S)-2-hydroxy acid and molecular oxygen to 2-oxo acid and hydrogen peroxide. In higher plants, GOX catalyzes the oxidation of glycolate to glyoxylate. GOX is part of the glyoxylate and dicarboxylate metabolism and uses FMN as a cofactor. GOX catalyzes the first step in the utilization of glycolate as the sole source of carbon. Structural highlights GOX structure shows the typical β8/α8 fold of an α-hydroxy acid oxidase and its active site contains the cofactor FMN.

spinqualitylabelsall models Human glycolate oxidase 1 complex with glyoxylte (PDB entry 2rdu) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of glycolate oxidase3D structures of glycolate oxidase

Updated on 14-March-2016

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• Glycolate oxidase
  • 1gyl – sGOX – spinach
    
  • 2nzl – hGOX1 – human
    
  • 2yvs – GOX GLCE subunit – Thermus thermophilus
    
  • 1tb3 – rGOX3 – rat
• Glycolate oxidase complex
  • 1al8, 1al7 – sGOX + inhibitor
    
  • 2rdu – hGOX1 + glyoxylate
    
  • 2rdw – hGOX1 + sulfate
    
  • 2w0u, 2rdt – hGOX1 + inhibitor
    
  • 3sgz – rGOX2 + inhibitor
    
  • 3giy – GOX1/(S)-mandelate dehydrogenase + MES – Pseudomonas putida