The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type (CASP Target)The 2.6 A crystal structure of the lipoxygenase domain of human arachidonate 12-lipoxygenase, 12S-type (CASP Target)

Structural highlights

3d3l is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Gene:ALOX12, LOG12 (HUMAN)
Activity:Arachidonate 12-lipoxygenase, with EC number 1.13.11.31
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LOX12_HUMAN] Oxygenase and 14,15-leukotriene A4 synthase activity.

Evolutionary Conservation

 

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

3d3l, resolution 2.60Å

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OCA