Fibronectin

Function Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion. Relevance Fn is associated with wound healing. Fn is a potential marker for radiation resistance. Disease Overexpression of Fn1 is associated with lung cancer. Structural insights Fn is a dimer of homologous monomers linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI6-FnII1-2-FnI7-9 is the gelatin binding domain (GBD).

spinqualitylabelsall models Human glycosylated fibronectin gelatin-binding domain complex with PEG400, dodecaethylene glycol and Zn+2 ions (grey) (PDB code 3m7p) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Fibronectin3D Structures of Fibronectin

Updated on 21-February-2016

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• Fn module FnI
  • 3m7p – hFn GBD – human
    
  • 1e8b, 1e88, 1qo6 - hFn GBD – NMR
    
  • 3gxe, 3ejh – hFnI_8-9 +collagen alpha-1
    
  • 1fbr - hFnI_4-5 - NMR
    
  • 2rky, 2rl0 – hFnI_4-5+Fn binding peptide
    
  • 2rkz, 3cal, 3zrz - hFn_2-3 +Fn binding peptide
    
  • 2cg6, 2cg7 - hFnI_2-3
    
  • 2cku - hFnI_2-3 – NMR
    
  • 1o9a - hFnI_1-2+B3 from FNBB – NMR
    
  • 2ec3 – hFnI₁₁ – NMR
    
  • 3r8q – hFnI_12-14
    
  • 1qgb – hFn FnI N-terminal - NMR
    
  • 2ck2 – hFn (mutant) core swapped
    
  • 1j8k – hFn extra domain 2 – NMR
    
  • 1fnh – hFn heparin and integrin binding domains
    
  • 2qbw, 3ch8 – hFn-PDZ fusion
    
  • 4gh7 – hFn residues 1173-1448 + Neutrophil gelatinase-associated lipocalin
• Fn module FnII
  • 2fn2 – hFnII₂ – NMR
• Fn module FnIII
  • 1q38, 1x3d, 1x4x, 1x5x - hFn FnIII – NMR
    
  • 2h41, 2h45 – hFnIII₂ – NMR
    
  • 1oww - hFnIII₁ – NMR
    
  • 2ha1 - hFnIII_1-2 – NMR
    
  • 2crm - hFnIII₄ – NMR
    
  • 2crz - hFnIII₅ – NMR
    
  • 1fna, 1ttf, 1ttg – hFnIII₁₀
    
  • 4mmx - hFnIII₁₀ + integrin α V + integrin β 3
    
  • 4mmy, 4mmz - hFnIII₁₀ (mutant) + integrin α V + integrin β 3
    
  • 2ocf - hFnIII₁₀+estrogen receptor ligand-binding domain
    
  • 1fnf – hFnIII_7-10
    
  • 2fnb – hFn FnIII ed-b domain – NMR
    
  • 1mfn, 2mfn – FnIII_9-10 – mouse - NMR
    
  • 2vmg, 2vmi - Fn FnIII carbohydrate-binding domain – Clostridium perfringens
• Fn module FnI+FnII
  • 3mql – hFnI₆+FnII₂+FnI₇