4ye6

The crystal structure of the intact human GlnRSThe crystal structure of the intact human GlnRS

4ye6 is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	4ye8, 4ye9
Activity:	Glutamine--tRNA ligase, with EC number 6.1.1.18
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum

[SYQ_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.

[SYQ_HUMAN] Plays a critical role in brain development.^[1]

↑ Zhang X, Ling J, Barcia G, Jing L, Wu J, Barry BJ, Mochida GH, Hill RS, Weimer JM, Stein Q, Poduri A, Partlow JN, Ville D, Dulac O, Yu TW, Lam AT, Servattalab S, Rodriguez J, Boddaert N, Munnich A, Colleaux L, Zon LI, Soll D, Walsh CA, Nabbout R. Mutations in QARS, encoding glutaminyl-tRNA synthetase, cause progressive microcephaly, cerebral-cerebellar atrophy, and intractable seizures. Am J Hum Genet. 2014 Apr 3;94(4):547-58. doi: 10.1016/j.ajhg.2014.03.003. Epub, 2014 Mar 20. PMID:24656866 doi:http://dx.doi.org/10.1016/j.ajhg.2014.03.003