Signalosome

COP9 (COnstitutive Photomorphogenesis 9) signalosome catalyzes the hydrolysis of NEDD8 protein from the cullin subunit of cullin-ring ubiquitin ligase. COP9 functions in the ubiquitin-proteasome pathway. COP9 contains 8 subunits and is homologous to the lid of the 26S proteasome^[1].

Human COP9 signalosome subunits 1 (grey and wheat), 2 (green and blue), 3 (pink and rust), 4 (yellow and aqua), 5 (magenta and olive), 6 (cyan and orchid), 7A (gold and turquoise), 8 (red and neon green) (PDB code 4d10)

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3D Structures of COP9 signalosome3D Structures of COP9 signalosome

Updated on 30-August-2016

4d0p – hCOP9 subunit 4 – human
1ufm – hCOP9 subunit 4 PCI domain - NMR
4f7o – hCOP9 subunit 5
4qft – hCOP9 subunit 6
4e0q, 4r14 – hCOP9 subunit 6 MPN domain
4d10, 4d18 – hCOP9 subunits 1,2,3,4,5,6,7A,8

ReferencesReferences

↑ Huang X, Hetfeld BK, Seifert U, Kahne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005 Aug;272(15):3909-17. PMID:16045761 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04807.x

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

[1] Huang X, Hetfeld BK, Seifert U, Kahne T, Kloetzel PM, Naumann M, Bech-Otschir D, Dubiel W. Consequences of COP9 signalosome and 26S proteasome interaction. FEBS J. 2005 Aug;272(15):3909-17. PMID:16045761 doi:http://dx.doi.org/10.1111/j.1742-4658.2005.04807.x

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