P63

P63 is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. Disease Mutations in P63 result in cleft lip or palate syndromes, split hand/foot malformation or ectodermal dysplasia.

spinqualitylabelsall models P63 DNA-binding domain complex with DNA and Zn+2 atoms (grey) (PDB code 3us0) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of P633D Structures of P63

Updated on 05-July-2015

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• P63 DBD
  • 2rmn – hP63 - human - NMR
    
  • 3qym, 3qyn, 3us0, 3us1, 3us2 – hP63 + DNA
    
• P63 tetramerization domain
  • 3zy0, 3zy1, 4a9z – hP63
    
• P63 C terminal domain
  • 1rg6 – hP63 - NMR
    
• P63 SAM domain
  • 2y9t – hP63 - NMR
    
  • 2y9u – hP63 (mutant)