Monooxygenase

Function Monooxygenases (MO) catalyzes the incorporation of a hydroxyl group into a variety of substrates. MO catalyzes the reduction of O2 to H2O while oxidating NADPH.

spinqualitylabelsall models Structure of heme-degrading monooxygenase with Fe containing heme complex with O2 molecule and Mg+2 (green) (PDB code 3lgn). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of monooxygenase3D structures of monooxygenase

Updated on 06-May-2015

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• Toluene 4-monooxygenase (TMO)
  • 3dhg, 3i5j – PmTMO α+β+γ subunits + Fe – Pseudomonas mendocina
    
  • 1sjg – PmTMO protein C + Fe
    
  • 1vm9 – PmTMO protein C (mutant) + Fe
    
• TMO complexes
  • 3dhh, 3q3n, 3q3o – PmTMO α+β+γ subunits + Fe + phenol derivative + TMO system effector protein
    
  • 3rmk – PmTMO α+β+γ subunits + Fe + phenol derivative
    
  • 3q14 – PmTMO α+β+γ subunits + Fe + p-cresol + TMO system effector protein
    
  • 3q2a, 3q3m – PmTMO α+β+γ subunits + Fe + benzoate inhibitor + TMO system effector protein
    
  • 3dhi – PmTMO α+β+γ subunits + Fe + TMO system effector protein
    
  • 3ge3, 3ge8, 3ri7 – PmTMO α (mutant)+β+γ subunits + Fe + TMO system effector protein
    
  • 3i63 – PmTMO α+β+γ subunits + Fe + TMO system effector protein + H2O2
    

Luceferin 4-monooxygenase and Alkanal monooxygenase See Luciferase

• Heme-degrading monooxygenase (IsdI)
  • 2zdp – SaIsdI + heme-Co – Staphylococcus aureus
    
  • 3lgm – SaIsdI + heme-Fe
    
  • 4fnh – SaIsdI (mutant) + heme-Fe
    
  • 3lgn – SaIsdI + heme-Fe + O2
    
  • 3qgp – SaIsdI + heme-Fe + CN
    
  • 4fni – SaIsdI (mutant) + heme-Fe + CN
    
• Kynurenine 3-monooxygenase (KMO)
  • 4j2w, 4j31, 4j33, 4j34 – yKMO + FAD – yeast
    
  • 4j36 – yKMO + FAD + inhibitor
    
• Phenol 2-monooxygenase (PMO)
  • 1foh – TcPMO + FAD – Trichosporon cutaneum
    
  • 1pn0 – TcPMO + FAD + phenol
    
• Phenylalanine 2-monooxygenase
  • 5pah, 6pah. – FMO catalytic domain + inhibitor – human
    
• ActVA-Orf6 monooxygenase (AOMO)
  • 1lq9 – ScAOMO – Streptomyces coelicolor
    
  • 1n5q – ScAOMO + sancycline
    
  • 1n5s, 1n5t – ScAOMO + acetyl dithranol
    
  • 1n5v – ScAOMO + nanaomycine
    
• Flavin-containing monooxygenase
  • 2gv8 – fyMO + FAD + NADP – fission yeast
    
  • 2gvc – fyMO + FAD + NADP + methimazole
    
  • 4a9w – MO + FAD – Stenotrophomonas maltophilia
    
  • 2i7g – MO – Agrobacterium tumefaciens
    

Methane monooxygenase See Methane monooxygenase

Camphor 5-monooxygenase See Cytochrome P450