Interferon regulatory factor

Interferon regulatory factor (IRF) regulate transcription of interferons. IRF-1 functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter. IRF-3 and IRF-7 are activated by viruses or after binding to Toll-like receptors. IRF-4 is lymphoid-specific and functions in the development of immune cells.

spinqualitylabelsall models Structure of mouse interferon regulatory factor DNA-binding domain dimer complex with DNA (PDB entry 1if1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of interferon regulatory factor3D structures of interferon regulatory factor

Updated on 27-November-2014

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• Interferon regulatory factor 1
  • 1if1 - mIRF DNA binding domain + DNA – mouse
• Interferon regulatory factor 2
  • 1irf, 1irg – mIRF DNA binding domain – NMR
    
  • 2irf - mIRF DNA binding domain + DNA
• Interferon regulatory factor 3
  • 1qwt, 1j2f – mIRF
    
  • 3a77 – hIRF DNA binding domain
    
  • 3qu6 - hIRF DNA binding domain (mutant)
    
  • 1t2k - hIRF DNA binding domain + interferon B enhancer + transcription factor AP-1 + DNA – human
    
  • 2o6g - hIRF DNA binding domain + interferon B enhancer
    
  • 2pi0 - hIRF DNA binding domain + interferon B promoter
    
  • 1zoq – hIRF + CREB-binding protein
    
  • 2o61 – hIRF3/IRF7/transcription factor + nuclear factor + DNA
• Interferon regulatory factor 4
  • 2dll – hIRF IRF domain - NMR
    
• Interferon regulatory factor 5
  • 3dsh – hIRF IRF domain (mutant)
• Interferon regulatory factor 7
  • 3qu3 - mIRF DNA binding domain

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