Catabolite control protein

Catabolite control protein (CcpA) is a regulator of carbon metabolism in gram-positive bacteria. When high concentrations of glucose-6 phosphate or fructose-1,6-diphosphate are present in the cell, they phosphorylate proteins HPr or Crh which interact with CcpA. The latter binds to DNA operator to modulate transcription.

spinqualitylabelsall models Structure of catabolite control protein (deepskyblue) complex with Hpr (green) and sulfate (PDB entry 2fep) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of catabolite control protein3D structures of catabolite control protein

Updated on 22-November-2015

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• CcpA
  • 2jcg, 2hsg - BmCcpA – Bacillus megaterium
    
  • 2o20 - CcpA (mutant) – Streptococcus lactis
    
• CcpA binary complex
  • 2oen - BmCcpA + phosphocarrier protein HPr
    
  • 2fep - BsCcpA + phosphocarrier protein HPr – Bacillus subtilis
    
• CcpA ternary complex
  • 1rzr – BmCcpA + phosphocarrier protein HPr + DNA
    
  • 2nzu - BmCcpA + phosphocarrier protein HPr + glucose-6-phosphate
    
  • 2nzv - BmCcpA + phosphocarrier protein HPr + fructose-1,6-diphosphate
    
  • 1zvv – BsCcpA + catabolite repression Crh + DNA
    
  • 3oqm, 3oqn, 3oqo - BsCcpA + phosphocarrier protein HPr + DNA