Template:STRUCTURE 2ayq
Isopropylmalate dehydrogenase (IMDH) catalyzes the oxidative decarboxylation of 3-isopropylmalate (3IPM) to 2-oxo-4-methylvalerate. This reaction is a step in the biosynthesis of leucine in bacteria and fungi. IMDH uses NAD as a cofactor. IMDH is a bifunctional enzyme that catalyzes dehydrogenation and decarboxylation in the presence of NAD and a divalent cation.
3D structures of isopropylmalate dehydrogenase3D structures of isopropylmalate dehydrogenase
Updated on 30-November-2014
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- 3-isopropylmalate dehydrogenase
- 1ipd, 1xaa, 1xab, 1xac, 1xad, 1osi, 1dpz, 1dr0, 1dr8, 2y3z – TtIMDH – Thermus thermophilus
- 1idm, 1osj, 1wal, 1gc8, 1gc9, 1g2u – TtIMDH (mutant)
- 2ayq, 1v53 – BcIMDH – Bacillus coagulans
- 1v5b – BcIMDH (mutant)
- 1cm7 – IMDH – Escherichia coli
- 1vlc – IMDH – Thermotoga maritima
- 1v7l - IMDH – Pyrococcus horikoshii
- 1w0d, 2g4o - MtIMDH - Mycobacterium tuberculosis
- 3h5e, 3h5h, 3h5j - MtIMDH small subunit
- 2hcu – IMDH small subunit – Streptococcus mutans
- 3q3w, 3udo - IMDH small subunit – Campylobacter jejuni
- 3r8w - IMDH – Arabidopsis thaliana
- 3u1h - IMDH – Bacillus
- 3vml - SoIMDH – Shewanella oneidensis/Shewanella benthica
- IMDH binary complexes
- 1hex – TtIMDH + NAD
- 2y40 - TtIMDH + Mn
- 1cnz – IMDH + Mn – Salmonella typhimurium
- 1wpw - IMDH + Mg – Sulfolobus tokodaii
- 2pkp - IMDH small subunit + Zn – Methanocaldococcus jannaschii
- 4iwh - IMDH + Mg – Burkholderia thailandensis
- IMDH ternary complexes
- 2y42 - TtIMDH + Mn + NAD
- 2ztw - TtIMDH + Mg + inhibitor + NAD
- 2y41 - TtIMDH + 3IPM + Mn
- 4f7i - TtIMDH + Mg + 3IPM + NAD
- 1a05 – IMDH + 3IPM + Mg - Acidithiobacillus ferrooxidans
- 3vkz, 3vl2, 3vl3, 3vl4, 3vl6, 3vl7 - SoIMDH + 3IPM + Ca
- 3vmj - SoIMDH + 3IPM + Mg
- 3vmk - IMDH + 3IPM + Mg – Shewanella bethica
- 2-isopropylmalate dehydrogenase
- 3fig - MtIMDH (mutant) + Zn