Template:STRUCTURE 3g6r
Glucocorticoid receptor (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD); hinge region; ligand-binding domain (LBD) and C terminal domain. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones.
3D structures of glucocorticoid receptor3D structures of glucocorticoid receptor
Updated on 26-November-2014
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- Glucocorticoid receptor DBD domain
- 1gdc, 2gda, 1rgd – rGCR DBD – NMR – rat
- 3g9p, 3fyl, 3g6p, 3g6q, 3g6r, 3g6t, 3g6u, 3g8u, 3g8x, 3g97, 3g99, 3g9i, 3g9m, 3g9j, 3g9o, 1glu, 1lat, 1r4o, 1r4r - rGCR DBD + DNA
- 4hn5, 4hn6 - hGCR DBD + DNA – human
- Glucocorticoid receptor LBD domain
- 1m2z, 3cld, 3bqd, 4lsj - hGCR LBD (mutant) + NCOA2 peptide + steroid
- 3e7c - hGCR LBD (mutant) + NCOA2 peptide + non-steroidal agonist
- 3k23 - hGCR LBD (mutant) + NCOA2 peptide + prolinamide
- 3k22 - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide
- 3h52 - hGCR LBD (mutant) + NCOA1 peptide + steroid
- 3gn8 - hGCR LBD + NCOA2 peptide + steroid
- 3ry9 - GCR LBD ancestral + steroid
- 4e2j - GCR LBD ancestral + NCOA2 peptide + steroid
- 3mne, 3mno, 3mnp - GCR LBD (mutant) + NCOA2 peptide + steroid
– mouse
- Glucocorticoid receptor LBD+hinge domains
- 1nhz – hGCR LBD+hinge (mutant) + steroid
- 1p93 - hGCR LBD+hinge (mutant) + NCOA2 peptide + steroid