| This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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The Na+/K+-ATPase is a transmembrane protein which generates an electrochemical gradient for sodium and potassium ions thanks to the hydrolysis of ATP. This pump exchanges 3Na+ for 2K+ (out) consuming 1ATP.
It belongs to the family of P-type ATPase, also known as E1-E2 ATPases, which are phosphorylated on an Aspartateresidue during the transport cycle.
It is vital to animal cells, to regulate their volume and to keep their homeostasis. Depending on the cells where the pump is, it allows the formation of a membrane potential or the transport of molecules through the membrane due to the created ionic concentration gradients.
These gradients provide energy for other secondary active transports.