4jc7
Human LTC4 synthase in complex with product analogs - implications for enzyme catalysisHuman LTC4 synthase in complex with product analogs - implications for enzyme catalysis
Template:ABSTRACT PUBMED 24366866
DiseaseDisease
[LTC4S_HUMAN] Defects in LTC4S are the cause of leukotriene C4 synthase deficiency (LTC4 synthase deficiency) [MIM:246530]. LTC4 synthase deficiency is a fatal neurometabolic developmental disorder. It is associated with muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly.
FunctionFunction
[LTC4S_HUMAN] Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.
About this StructureAbout this Structure
4jc7 is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Niegowski D, Kleinschmidt T, Olsson U, Ahmad S, Rinaldo-Matthis A, Haeggstrom JZ. Crystal structures of Leukotriene C4 synthase in complex with product analogs, implications for the enzyme mechanism. J Biol Chem. 2013 Dec 23. PMID:24366866 doi:http://dx.doi.org/10.1074/jbc.M113.534628