1slp
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FIRST STEM LOOP OF THE SL1 RNA FROM CAENORHABDITIS ELEGANS, NMR, 16 STRUCTURES
OverviewOverview
BACKGROUND: RNA splicing is both ubiquitous and essential for the, maturation of precursor mRNA molecules in eukaryotes. The process of, trans-splicing involves the transfer of a short spliced leader (SL) RNA, sequence to a consensus acceptor site on a separate pre-mRNA transcript., In Caenorhabditis elegans, a majority of pre-mRNA transcripts receive the, 22-nucleotide SL from the SL1 RNA. Very little is known about the various, roles that RNA structures play in the complex conformational, rearrangements and reactions involved in premRNA splicing. RESULTS: We, have determined the solution structure of a domain of the first stem loop, of the SL1 RNA of C. elegans, using homonuclear and heteronuclear NMR, techniques; this domain contains the splice-donor site and a, nine-nucleotide hairpin ... [(full description)]
About this StructureAbout this Structure
1SLP is a [Protein complex] structure of sequences from [Caenorhabditis elegans]. Structure known Active Site: SPL. Full crystallographic information is available from [OCA].
ReferenceReference
Solution structure of the donor site of a trans-splicing RNA., Greenbaum NL, Radhakrishnan I, Patel DJ, Hirsh D, Structure. 1996 Jun 15;4(6):725-33. PMID:8805553
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