4c8d

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Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)

Structural highlights

4c8d is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, , , ,
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[KDM3B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.[1]

References

  1. ↑ Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006 May 5;125(3):483-95. Epub 2006 Apr 6. PMID:16603237 doi:http://dx.doi.org/S0092-8674(06)00385-0

4c8d, resolution 2.18Å

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