4l87

Crystal structure of the human seryl-tRNA synthetase in complex with Ser-SA at 2.9 Angstrom resolutionCrystal structure of the human seryl-tRNA synthetase in complex with Ser-SA at 2.9 Angstrom resolution

FunctionFunction

[SYSC_HUMAN] Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).^[1]

About this StructureAbout this Structure

4l87 is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

ReferenceReference

^{[xtra 1]}

↑ Xu X, Shi Y, Yang XL. Crystal Structure of Human Seryl-tRNA Synthetase and Ser-SA Complex Reveals a Molecular Lever Specific to Higher Eukaryotes. Structure. 2013 Oct 1. pii: S0969-2126(13)00342-0. doi:, 10.1016/j.str.2013.08.021. PMID:24095058 doi:http://dx.doi.org/10.1016/j.str.2013.08.021

↑ Vincent C, Tarbouriech N, Hartlein M. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. Eur J Biochem. 1997 Nov 15;250(1):77-84. PMID:9431993

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OCA

[2] Xu X, Shi Y, Yang XL. Crystal Structure of Human Seryl-tRNA Synthetase and Ser-SA Complex Reveals a Molecular Lever Specific to Higher Eukaryotes. Structure. 2013 Oct 1. pii: S0969-2126(13)00342-0. doi:, 10.1016/j.str.2013.08.021. PMID:24095058 doi:http://dx.doi.org/10.1016/j.str.2013.08.021

[1] Vincent C, Tarbouriech N, Hartlein M. Genomic organization, cDNA sequence, bacterial expression, and purification of human seryl-tRNA synthase. Eur J Biochem. 1997 Nov 15;250(1):77-84. PMID:9431993

[1]

[xtra 1]