4mbl

Discovery of Pyrazolo[1,5a]pyrimidine-based Pim1 InhibitorsDiscovery of Pyrazolo[1,5a]pyrimidine-based Pim1 Inhibitors

Structural highlights 4mbl is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: Related: 4mbi Gene: PIM1 (Homo sapiens) Activity: Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan-Pim inhibitors such as 11j are described. Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach.,Dwyer MP, Keertikar K, Paruch K, Alvarez C, Labroli M, Poker C, Fischmann TO, Mayer-Ezell R, Bond R, Wang Y, Azevedo R, Guzi TJ Bioorg Med Chem Lett. 2013 Nov 15;23(22):6178-82. doi:, 10.1016/j.bmcl.2013.08.110. Epub 2013 Sep 7. PMID:24091081 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 4mbl, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image