Sandbox 1k4r

Dengue VirusDengue Virus

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1k4r, resolution 24.00Å ()
Related:	1svb
Structural annotation: Resources: InterPro : Ipr009003, Ipr011492, Ipr000752, Ipr001122, Ipr001157, Ipr011998, Ipr011999, Ipr013754, Ipr014001, Ipr014021, Ipr014412, Ipr014756, Ipr002535, Ipr002877, Ipr007094, Ipr001528, Ipr001650, Ipr001850, Ipr000069, Ipr000208, Ipr000336, Ipr000404, Ipr000487 Pfam : PF02832, PF00869 SCOP : d1k4ra_, d1k4rb_, d1k4rc_ UniProt : P07720
Evolutionary conservation: Toggle Conservation Colors: Rows = identical sequences: Further Information: Caveats, Explanation, Complete Results at ConSurfDB
Resources:	FirstGlance, OCA, RCSB, PDBsum
Coordinates:	save as pdb, mmCIF, xml

Structure of Dengue VirusStructure of Dengue Virus

Publication Abstract from PubMed

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The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per icosahedral asymmetric unit do not have quasiequivalent symmetric environments. Difference maps indicate the location of the small membrane protein M relative to the overlaying scaffold of E dimers. The structure suggests that flaviviruses, and by analogy also alphaviruses, employ a fusion mechanism in which the distal beta barrels of domain II of the glycoprotein E are inserted into the cellular membrane.

Structure of dengue virus: implications for flavivirus organization, maturation, and fusion., Kuhn RJ, Zhang W, Rossmann MG, Pletnev SV, Corver J, Lenches E, Jones CT, Mukhopadhyay S, Chipman PR, Strauss EG, Baker TS, Strauss JH, Cell. 2002 Mar 8;108(5):717-25. PMID:11893341

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

EtiologyEtiology

Dengue virus is a mosquito borne illness and is a major threat in most of the tropical and sub-tropical countries around the world. There are four related subtypes of the Dengue virus. Dengue is not transmitted directly from person-to-person and symptoms range from a mild fever, to incapacitating high fever, with severe headache, pain behind the eyes, muscle and joint pain, and rash. There is no vaccine or any specific medicine to treat dengue. People who have dengue fever should rest, drink plenty of fluids and reduce the fever using paracetamol or see a doctor.

About this StructureAbout this Structure

File:1k4rVirion.png