4mza
Crystal structure of hPIV3 hemagglutinin-neuraminidaseCrystal structure of hPIV3 hemagglutinin-neuraminidase
Template:ABSTRACT PUBMED 24149514
FunctionFunction
[HN_PI3H4] Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins (By similarity).
About this StructureAbout this Structure
4mza is a 2 chain structure with sequence from Human parainfluenza 3 virus (strain nih 47885). Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Xu R, Palmer SG, Porotto M, Palermo LM, Niewiesk S, Wilson IA, Moscona A. Interaction between the Hemagglutinin-Neuraminidase and Fusion Glycoproteins of Human Parainfluenza Virus Type III Regulates Viral Growth In Vivo. MBio. 2013 Oct 22;4(5). pii: e00803-13. doi: 10.1128/mBio.00803-13. PMID:24149514 doi:http://dx.doi.org/10.1128/mBio.00803-13