4mda
Structure of Mos1 transposase catalytic domain and Raltegravir with MnStructure of Mos1 transposase catalytic domain and Raltegravir with Mn
Template:ABSTRACT PUBMED 24397848
FunctionFunction
[MOS1T_DROMA] Mediates transposition of transposon Mos1 by a 'cut and paste' mechanism. Transposases are sequence-specific nucleases and strand transferases that catalyze transposition through an ordered series of events: sequence-specific binding of transposase to the terminal inverted repeats (IR) present at each end of the transposon, pairing of the transposon IRs in a paired-end complex (PEC), cleavage of one or both DNA strands at each transposon end, capture of target DNA, and strand transfer to insert the transposon at a new site.
About this StructureAbout this Structure
4mda is a 1 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Wolkowicz UM, Morris ER, Robson M, Trubitsyna M, Richardson JM. Structural Basis of Mos1 Transposase Inhibition by the Anti-retroviral Drug Raltegravir. ACS Chem Biol. 2014 Jan 10. PMID:24397848 doi:http://dx.doi.org/10.1021/cb400791u