4c0a
Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domainArf1(Delta1-17)in complex with BRAG2 Sec7-PH domain
FunctionFunction
[ARF1_BOVIN] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
About this StructureAbout this Structure
4c0a is a 8 chain structure with sequence from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.