Structural highlights
4kg8 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Related: | 4en0, 4j6g, 4fhq, 3k51, 3mi8, 3mhd |
| Gene: | TNFSF14, HVEML, LIGHT, UNQ391/PRO726 (Homo sapiens) |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[TNF14_HUMAN] Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.